Mechanisms underlying skin disorders induced by EGFR inhibitors

Mechanisms underlying skin disorders induced by EGFR inhibitors

The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase that is frequently mutated or overexpressed in a large number of tumors such as carcinomas or glioblastoma. Inhibitors of EGFR activation have been successfully established for the therapy of some cancers and are more and more frequently being used as first or later line therapies. Although the side effects induced by inh...

Novel EGFR inhibitors attenuate cardiac hypertrophy induced by angiotensin II

Cardiac hypertrophy is an important risk factor for heart failure. Epidermal growth factor receptor (EGFR) has been found to play a role in the pathogenesis of various cardiovascular diseases. The aim of this current study was to examine the role of EGFR in angiotensin II (Ang II)-induced cardiac hypertrophy and identify the underlying molecular mechanisms. In this study, we observed that both ...

Mechanisms Underlying Leptin- induced Cardioprotection

Introduction Activation of the Reperfusion Injury SalvageKinase (RISK) pathway, which incorporates phosphatidyli-nositol-3-OH kinase (PI3K)-Akt/protein kinase B (PKB) andp44/42 mitogen-activated protein kinase (MAPK), underliesprotection against ischemia–reperfusion (I/R) injury. Thetemporal nature of the activation of these RISK pathwaycomponents during reperfusion ...

Mechanisms Underlying Aggregation Induced Immunogenicity

Mechanisms underlying neuronal death induced by chromogranin A-activated microglia.

The neurotoxic effects of activated microglia in neurodegenerative diseases are well established. We recently provided evidence that chromogranin A (CGA), a multifunctional protein localized in dystrophic neurites and in senile plaques, induces an activated phenotype and secretion of neurotoxins by rat microglia in culture. In the present study, we focused on the mechanisms underlying neuronal ...